Xiaoyu Tang, PhD

Post-Doctoral Fellow


858-200-1888

Bio

Xiaoyu Tang, PhD is a post-doctoral fellow at the J. Craig Venter Institute under the supervision of Dr. Anna Edlund. Dr. Tang has had a long-standing interest and a demonstrated record of productive multidisciplinary research in studying microbial small molecules and their effects on human health.  He joined JCVI in March 2017, where he began combining chemical, genetic, and genomics approaches to identify and study microbial small molecules from the human oral microbiome. Dr. Tang also holds a visiting scholar position at the Scripps Institution of Oceanography. Prior to his current engagement, Dr. Tang was a post-doctoral researcher in the laboratory of Dr. Bradley S. Moore at UC San Diego. Dr. Tang completed his PhD in Pharmaceutical Sciences at the Eberhard Karls University of Tübingen in Germany in 2013. He was awarded the PHOENIX Pharmaceutical Science Award in 2014, which is one of the most prestigious German science awards.

Research Priorities

  • Discovering diffusible and microbe-associated small molecules from the human oral microbiome.
  • Investigating small molecule biosynthesis and regulation.
  • Scrutinizing the biological and ecological roles of small molecules in oral biofilm communities.
Enzymatic C-H Oxidation-Amidation Cascade in the Production of Natural and Unnatural Thiotetronate Antibiotics with Potentiated Bioactivity.
Angewandte Chemie (International ed. in English). 2017-09-25; 56.40: 12234-12239.
PMID: 28833969
Broad-Host-Range Expression Reveals Native and Host Regulatory Elements That Influence Heterologous Antibiotic Production in Gram-Negative Bacteria.
mBio. 2017-09-05; 8.5:
PMID: 28874475
Minimization of the Thiolactomycin Biosynthetic Pathway Reveals that the Cytochrome P450 Enzyme TlmF Is Required for Five-Membered Thiolactone Ring Formation.
Chembiochem : a European journal of chemical biology. 2017-06-19; 18.12: 1072-1076.
PMID: 28393452
Identification of Thiotetronic Acid Antibiotic Biosynthetic Pathways by Target-directed Genome Mining.
ACS chemical biology. 2015-12-18; 10.12: 2841-2849.
PMID: 26458099
Identification of mureidomycin analogues and functional analysis of an N-acetyltransferase in napsamycin biosynthesis.
Chembiochem : a European journal of chemical biology. 2013-11-25; 14.17: 2248-55.
PMID: 24115404
A two-step sulfation in antibiotic biosynthesis requires a type III polyketide synthase.
Nature chemical biology. 2013-10-01; 9.10: 610-5.
PMID: 23912167
The biosynthesis of caprazamycins and related liponucleoside antibiotics: new insights.
Biological chemistry. 2013-02-01; 394.2: 251-9.
PMID: 23104838
Identification of a napsamycin biosynthesis gene cluster by genome mining.
Chembiochem : a European journal of chemical biology. 2011-02-11; 12.3: 477-87.
PMID: 21290549
Biochemical properties and potential applications of a solvent-stable protease from the high-yield protease producer Pseudomonas aeruginosa PT121.
Applied biochemistry and biotechnology. 2010-02-01; 160.4: 1017-31.
PMID: 19455429
Screening and isolation of an organic solvent-tolerant bacterium for high-yield production of organic solvent-stable protease.
Bioresource technology. 2008-10-01; 99.15: 7388-92.
PMID: 18346890