Introduction

Disease phenotypes arise from complex interactions of organisms with their environments.

While we have a long history of associating genes and gene defects with a large array of disease phenotypes, a growing body of data suggests that many disease phenotypes arise from the interaction of genes with their environments, including the genetic background in which the genes are expressed.

Our goal is to begin exploration of these interactions using rodent models of human disease and cDNA microarray assays to elucidate patterns of gene expression in heart, lung, blood, and sleep disorders.

See an overview of the data-browsing sections of the site.

This project is one of eleven funded
Programs for Genomic Applications (PGAs)
funded through the
National Heart, Lung, and Blood Institute (NHLBI)
Additional information may be found at the All PGA search page.